Isaac Asimov’s classic sci-fi series tells of the predicted downfall of the Galactic Empire.  Hari Seldon devised a system of mathematics to predict the future.  Called psychohistory, Seldon found you could predict history over huge timespans.  Individuals are unpredictable but the masses can be predicted.  Seldon formed the Foundation to lessen the dark ages after the fall of the Galactic Empire, but Seldon’s millennia worth of predictions could be destroyed by one unpredictable individual.  The powerful psionic the Mule was that individual.  Able to control the emotions of others, the Mule formed a massive empire to defeat the Foundation.  The Mule can be remembered as one of the scariest and most twisted villains in science fiction, from his freakish look to some of his bizarre traits (like infertility).  It easy to say the Mule is the greatest infertile super-villain in geek history.  And that’s something to be proud of.